ACIDOS MICOLICOS PDF

Los ácidos micólicos, en específico, poseen funciones biológicas importantes, entre las que se encuentra el papel que desempeñan en la persistencia de la. como los ácidos micólicos, ácido micoserósido, fenoltiocerol, lipoarabinomanano y arabinogalactano contribuyen a la longevidad, a la respuesta inflamatoria. Aunque el análisis de los lípidos de la pared celular (ácidos micólicos) mediante cromatografía líquida de alta presión es una opción Buena y bien conocida, los.

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Brennan PJ, Nikaido H. Discovery of a novel and potent class of FabI-directed antibacterial agents. Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis. Estes pesquisadores isolaram cepas de E. Tuberculosis, Mycobacterium smegmatis, lipids. Some observations on the pathogenicity of isoniazid-resistant variants of tubercle bacilli. The effect of the acidps of human gamma globulins in a model of BCG infection in mice.

Overexpression of inhA, but not kasAconfers resistance to isoniazid and ethionamide in Mycobacterium smegmatisM. Advances in tuberculosis vacine strategies. Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: The envelope of mycobateria.

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Tal es el caso del estudio desarrollado por Mederos y cols. Oxford University Press, The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. However, the biochemical and functional differences between the bacterial and mammals’ fatty acid synthetic pathway have endowed the mycobacterial enzymes with distinct properties.

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Dot blot de micolicoa extraidos de Mycobacterium smegmatis.

Ácido micólico – Wikipedia, a enciclopedia libre

Mechanistic diversity and regulation of Type II fatty acid synthesis. Crystal structure and fuction micolixos the isoniazid target of Mycobacterium tuberculosis. Molecular Microbiology ; Chemotherapy of experimental tuberculosis – V. Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea model of tuberculosis.

The history of the Ziehl-Neelsen stain. A triclosan-resistant bacterial enzyme. The enoyl-reductases are essential enzymes in the fatty acids elongation pathway towards the mycolic acids, the main mycobacteria cell wall constituents, biosynthesis and so they are potential targets to the rational new antimycobacteria drug design. J Biol Chem ; Rev Latinoam Microbiol ; 48 2: Pathogenic and potentially pathogenic microorganisms as contaminants of fresh water from different sources.

Broad spectrum antimicrobial biocides target the FabI component of fatty acid biosynthesis. Biosynthesis of mycobacterial lipoarabinomannan: Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP CoA reductase from Mycobacterium tuberculosis.

Ciudad de la Habana, Cuba. J Gen Appl Microbiol ; Drug sensitivity and environmental adaptation of mycobacterial cell wall components. These provide valuable opportunities for structure- or catalytic mechanism-based design of selective inhibitors as novel anti-TB drugs with improved properties. Fatty acid biosynthesis is a prokariontes and eucariontes biochemical process that supplies essential precursors for the assembly of important cellular components, such as phospholipids, lipoproteins, lipopolysaccharides, mycolic acids and cellular envelope.

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Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. Em geral, as tiofeno-diazoborinas foram os inibidores mais potentes, seguidos pelas benzo-diazoborinas e furano-diazoborinas, enquanto que as pirrol-diazoborinas foram totalmente inativas.

The global tuberculosis situation: Constructing protein models for ligand-receptor binding thermodynamic simulations: J Exp Med ; Chemotherapy of experimental tuberculosis – VI. Services on Demand Journal.

Mainly we identified the presence of phospholipids and micolic acids in the lipid extract showing a high recognition by human gammaglobulin. Infection and Immunity ; The mechanism of isoniazid killing: Surface glycopeptidolipids of M. Cepa bacteriana y condiciones de crecimiento. Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents. Application to a set of peptidometic rennin inhibitors.

Ácido micólico

Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics. Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Global tuberculosis incidence and mortality during acidps Evaluation of Mycobacterium smegmatis as a possible surrogate screen for selecting molecules active against multi-drug resistant Mycobacterium tuberculosis.

Characterization of a ligand-receptor binding event using receptor-dependent four-dimensional quantitative structure-activity relationship analysis.