Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive.

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Conditions of the skin appendages Condition of the skin appendages stubs. A year-old male patient presented with asymptomatic lesion over nose since 2 years to the outpatient department of dermatology and leprosy. Other differential diagnosis include acne vulgaris, lupus pernio, and lupus erythematosus. On diascopy, lesions used to disappear; however, they used to reappear after relieving the pressure.

Triangular alopecia Frontal fibrosing alopecia Marie Unna hereditary hypotrichosis.

Table of Contents Alerts. Treatment of granulosis rubra nasi with botulinum toxin type A. Koilonychia Nail clubbing behavior: A Patchy mononuclear cell infiltration in upper dermis with dilatation of capillaries and lymphatics Haematoxylin and Eosin stain x ; B patchy mononuclear cell infiltration with dilatation of capillaries and nasii Haematoxylin and Eosin stain x ; C mononuclear cell infiltration around sweat duct Haematoxylin and Eosin stain x New lesions kept appearing.

It usually starts in childhood in patients aged between 6 months and 15 years.


Granulosis rubra nasi: a rare condition treated successfully with topical tacrolimus

Similar infiltration around sweat ducts too was noticed Figure 2 C. View at Google Scholar G. The diagnosis is usually granulpsis. Case Report A 20 years-old girl presented with multiple discrete asymptomatic reddish vesicles over cheeks, nose, and forehead for four years Figure 1. Goldsmith had described rhino rrhea as an associated feature.

Granulosis rubra nasi | Primary Care Dermatology Society | UK

Most of these lesions were reddish in colour and expressed small amount of serosanguineous fluid. In acute lupus erythematosus, there is a granuloosis rash with mouth ulcers but there is no hyperhidrosis. No preventive measures or complications are reported and the disease has an excellent prognosis with self resolution at puberty in most cases.

Treatment is symptomatic and cosmetic. Granulosis rubra nasi usually resolves spontaneously around puberty ; however, it occasionally persists indefinitely Treatment with glycopyrronium bromide cream, a topical anti-cholinergic, can improve symptoms Botulinum toxin injections have also been reported as effective.

A 20 years-old girl presented with multiple discrete asymptomatic reddish vesicles over cheeks, nose, and forehead for four years Figure 1. Dermis shows dilated eccrine sweat glands. She had first noticed redness and increased sweating over central face 10 years back. Hyperhidrosis and botulinum toxic in dermatology.

It is an inflammatory dermatosis involving eccrine sweat glands of central face involving nose, cheeks, or chin, representing a unique sweat retention form [ 2 ].


Miliaria crystallina presents with vesicles mainly over the areas occluded by clothes. There is moderately peri-infundibular infiltrate of lymphocytes and plasma cells. View at Google Scholar O.

Erythema may gradually extend to involve upper lip, cheeks, and chin with sweat droplets studded over, giving glistening appearance. After 15 days of follow-up, the patient has shown good nask Figure 3. Other differential diagnoses include acne vulgaris, lupus pernio, lupus erythematosus, lupus vulgaris, leishmaniasis, actinic keratosis or skin cancer, miliaria crystallina, and hidrocystoma [ 2410 ]. However, telangiectatic blood vessels and some erythema were still persisting. Acne vulgaris presents with comedones, papules, and rubta without hyperhidrosis and telangiectasia.

Shows erythema more prominently.

Case Reports in Dermatological Medicine

Notice and credit must be given to the PCDS or other named contributor. It used to get worse in summer and was associated with localized hyperhidrosis.

The skin biopsy showed dilatation of blood vessels, dilated sweat ducts with a discrete mononuclear cell infiltrate surrounding them [ Figure 3 ]. Open in a separate window. There is dilation of blood vessels and the lymphatic vessels.